Scavenging new insights into atherogenesis

Scavenging new insights into atherogenesis.

Atherogenesis--recent insights into basic mechanisms and their clinical impact.

Prior to the development of atherosclerotic plaques, endothelial vasodilator function is impaired early in the process of atherogenesis. The endothelium is not only a single cell layered mechanical barrier between the blood and vessel wall, but regulates various important functions of the vasculature such as vasomotion and, therefore, blood flow regulation, as well as haemostasis and wall proli...

Adaptive immunity in atherogenesis: new insights and therapeutic approaches.

Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and a...

New insights into PTEN.

The functions ascribed to PTEN have become more diverse since its discovery as a putative phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and proteins, it also has functions independent of phosphatase activity in normal and pathological states. In addition, control of PTEN function is very complex. It is positively and negatively regulated at the transcriptional...

New Insights Into Mechanisms

Obesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and ren...